Health & Safety
7 min read
GLP-1 Side Effects: What’s Normal and When to Call Your Doctor
GLP-1 medications like compounded semaglutide and tirzepatide are highly effective for weight management, but like any medication, they can cause side effects. Understanding what is normal and how to manage these side effects is a crucial part of your treatment journey.
In this article, we outline the most common side effects of GLP-1s and provide guidance on when you should seek medical advice.
Common and Expected Side Effects
The majority of side effects associated with GLP-1 medications are gastrointestinal. This is because these medications intentionally slow down gastric emptying (the rate at which food leaves your stomach).
These side effects are most common when you first start the medication or shortly after increasing your dose (titration). They typically subside as your body adjusts.
Common side effects include:
Nausea: The most frequently reported side effect. It is often mild and manageable.
Constipation or Diarrhea: Changes in bowel habits are common due to slower digestion.
Upset Stomach or Indigestion: Feeling overly full or bloated, especially after eating a large meal.
Fatigue: Some patients report feeling tired, particularly in the first few weeks.
How to Manage Common Side Effects
You can often mitigate these side effects with simple lifestyle adjustments:
Eat smaller meals: Avoid overeating, as a full stomach can trigger nausea.
Avoid high-fat and greasy foods: These are harder to digest and can worsen gastrointestinal discomfort.
Stay hydrated: Drink plenty of water, especially if you experience diarrhea or constipation.
Eat slowly: Give your brain time to register that you are full.
When to Contact Your Care Team
While mild gastrointestinal side effects are normal, certain symptoms require medical attention. You should contact your Fig care team or seek immediate medical care if you experience:
Severe or persistent abdominal pain: Especially if the pain radiates to your back, which could be a sign of pancreatitis.
Inability to keep liquids down: Severe vomiting that leads to dehydration.
Changes in vision: Particularly if you have a history of diabetic retinopathy.
Signs of an allergic reaction: Such as swelling of the face, lips, tongue, or throat, or difficulty breathing.
24/7 Support with Fig
At Fig, your safety and comfort are our top priorities. That is why every treatment plan includes 24/7 unlimited messaging with your dedicated care team. If you are struggling with side effects, reach out. We can provide guidance or adjust your titration schedule to ensure your treatment is as comfortable as possible.
Take the free online assessment at Fig today to begin your medically supervised weight loss journey.
Medical Disclaimer: Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, effectiveness, or quality. Fig does not guarantee weight loss results. Individual outcomes vary. Treatment is only prescribed when a licensed provider determines it is clinically appropriate.